Transcript · English → Chinese
Bioelectricity and Cancer Research
我非常想研究癌症， 也非常想研究这个，呃，
这个
想法，呃， 其中有生物电成分。
而且，而且，你可以， 你可以简单地理解为—
为—
不是为什么会有癌症，而是为什么 会有癌症以外的任何东西？
所以， 细胞为何会合作，而不是
变成阿米巴？
它们为什么会合作？ 因此，我们知道生物电
信号是
某种，呃，认知黏合剂， 将它们凝聚到这些
大规模建造工程中， 维持器官等等。
所以，呃，对， 我们想研究
它的生物电机制。
所以我有，我有两名学生，呃， Brooke Tchernit，还有，呃，Maria
Lobikin，她们，呃，着手进行了这项工 作， 而我们得以
证明利用这种生物电 成像，你能提前判断哪些
细胞将会发生转化。
你还可以说服完全正常的 细胞变成
转移性黑色素瘤，只需给它们 关于其环境的不当生物电信号。
所以你可以强— —你可以说服——不需要基因损伤，也不需要
致癌物，也不需要，你知道的，致癌基 因， 只要错误的生物电
信息，它们就会变成，呃， 像转移性黑色素瘤那样。
嗯，而且最重要的是，他们 能够证明
你实际上可以逆转，
不是反反反转，嗯， 例如人类致癌基因这类致癌刺激，
通过与邻近细胞建立恰当的 生物电连接。
所以我们有一整套，呃， 我们有一整套论文，嗯，
所以我们有一整套，呃， 我们有一整套论文，嗯，
展示如何
呃，如何用生物电控制细—— 胞。
而且，呃，呃，我实验室里的胡安妮塔· 马修斯现在，呃，
正试图把，
呃，把所有那些策略用于人类， 用于人类癌症
End of transcript · 285 words · machine translated
Original transcript (English)
I really wanted to work on cancer, and I really wanted to work on this, um, on this idea that, uh, there's a bioelectric component to it. And, and the, and the way you can, you can think about it is simply that w- w-
not why is there cancer, but why is there anything but cancer? So, so why do cells ever cooperate instead of being amoebas? Why do they ever cooperate? And so we know that the bioelectric signaling is the
kind of, um, cognitive glue that, that binds them together towards these large scale construction projects, maintaining organs and things like that. And so, um, yeah, so we wanted to study that bioelectrically. And so I had, I had two students, uh, Brooke Tchernit and, uh, Maria
Lobikin, who, uh, undertook that, and we were able to show that using this bioelectrical imaging, you can tell which cells were going to convert ahead of time. You could also convince perfectly normal cells to become metastatic melanoma just by giving them inappropriate bioelectric cues about
their environment. So you can f-- you can co-- no, no genetic damage, no carcinogens, no, you know, oncogenes, but, but just the wrong bioelectric information, and they become, uh, like metastatic melanoma. Um, and, and best of all, they were able to show that you can actually reverse,
not re-re-reverse, um, a carcinogenic stimuli, for example, human oncogenes, by appropriate bioelectric connections to their neighbors. So we had a whole set of, uh, we had a whole set of papers, um, showing how
to, uh, how to control s- cells bioelectrically. And, uh, uh, Juanita Matthews in my lab now is, uh, trying to take, um, take all those strategies into human, into human cancer
