抗抑郁药、自杀风险与治疗失败后的绝望感

If these drugs are like numbing, they're detaching you from the intensity of the experience.

What is happening when there's these known risks of inducing suicide?

I think I haven't, I'm not an expert on that part of the literature, but I have ideas.

I think there is a, there must be some direct way that that drug just induces that thought,

that idea, that sensation.

I think there is a direct way, as there is with weight gain, for example, stupid example, maybe,

but there's definitely a direct way for an antipsychotic to cause weight gain.

And there's an indirect way, meaning that you crave more, eat more.

There's certainly people who gain on weight without even eating more.

So I think there is a direct way.

Like metabolic functioning.

Like metabolic way, exactly.

And for some reason, I'm not an expert on how that would work.

There must be one as such for suicide attempts and thoughts and ideation.

But I also think there is an indirect way if you've had presented,

if that was presented to you as the ultimate treatment, the best one we've got.

And that turns out to not work.

Well, there's not far from that and suicide.

Like obviously, if you, if I'm presenting this, this is the gold standard of treatment.

If you keep hearing that narrative and it doesn't work for you, as it doesn't for most antidepressants,

well, what's left then?

That's really a recipe for the hopelessness that we know that suicide is a strategy to solve.

Like suicide is the ultimate strategy to get out of something really.

And actually, it can feel pretty relieving for someone in the moment when they're really distressed.

The idea of having to take their own life.

So that can come into the category of strategies too.

And that strategy obviously makes more sense the more you think it's hopeless.

And the more you've had drugs presented to you as the best thing we have and that not working.